The Penicillin: Scotch Whiskey’s Perfect Prescription

Mastering The Penicillin Cocktail: A Zesty Scotch Whiskey Elixir

The Penicillin is more than just a Scotch Whiskey cocktail; it’s a beautifully balanced concoction marrying the bright notes of lemon, the comforting sweetness of honey, and the invigorating kick of ginger, all underscored by the complex character of Scotch. In this comprehensive guide, we’ll delve into its fascinating origins, explore its unique flavor profile, and provide a detailed, easy-to-follow recipe so you can craft this intriguing drink at home. Discover what makes “The Penicillin” such an iconic cocktail and why its name holds a charming secret!

Scotch Whiskey Cocktail: The Penicillin // FoodNouveau.com

This post contains affiliate links. Full disclosure is at the bottom of the article.


While my home bar might not always be stocked for elaborate mixology sessions, when I do venture into cocktail crafting, I gravitate towards drinks that promise both ease and a vibrant, zesty flavor profile. Classics like a refreshing Paloma cocktail or a minty Mojito often fit the bill perfectly.

However, when the opportunity arises to visit a top-tier restaurant or a dedicated cocktail bar known for its masterful creations, I seize the chance to indulge in something truly innovative and memorable. A few years ago, during a trip to the bustling culinary scene of Los Angeles, I noticed a distinct trend: Scotch whiskey cocktails were prominently featured on almost every sophisticated drink menu. This was quite a revelation for me.

Living with a devoted Scotch whiskey aficionado, I had always viewed Scotch as a spirit to be enjoyed neat, savored for its intricate flavors without adornment. The idea of mixing it into a cocktail seemed almost sacrilegious, not to mention the thought of using one of his prized, often expensive, bottles in a shaken drink! Moreover, for my palate, Scotch had always been a bit too robust and intense to fully appreciate on its own.

Yet, the widespread popularity of Scotch whiskey cocktails in LA sparked my curiosity. After encountering “The Penicillin” repeatedly on various menus, its unique combination of ingredients – bright lemon, soothing honey, and spicy ginger – immediately captivated me. These were flavors I inherently loved, and the promise of them alongside Scotch was too intriguing to pass up. With a leap of faith, I ordered one.

It was, quite simply, love at first sip. The Penicillin cocktail was an unexpected symphony of flavors: smoky yet refreshing, spicy yet sweet, and perfectly balanced. I was instantly hooked. My trip quickly evolved into a delightful quest to sample as many Penicillin cocktails as I could find, each bar offering its subtle twist on the classic. Rest assured, these tastings were spread out over several evenings, allowing me to truly appreciate each nuance and understand why this drink had become such a phenomenon.

The ingredients you need to make The Penicillin cocktail, a zesty drink make with Scotch whiskey // FoodNouveau.com


Unveiling The Penicillin: History and Flavor Profile


Who Invented The Penicillin Cocktail?

The Penicillin cocktail is a modern classic, a testament to contemporary mixology. It was expertly crafted in 2005 by Australian bartender Sam Ross. At the time, Ross was honing his skills and pushing creative boundaries at the renowned Manhattan bar, Milk & Honey. This speakeasy-style establishment was famous for its innovative approach to cocktails and its commitment to quality ingredients, making it the perfect birthplace for such an iconic drink.

Why Is It Called The Penicillin Cocktail?

The clever, almost whimsical, name of “The Penicillin” is a playful nod to two of its most prominent and comforting ingredients: honey and ginger. Both have long been revered for their perceived medicinal properties and are frequently combined and consumed when one feels unwell. Think of the soothing effect of honey-lemon cough drops, ginger tea, or a spoonful of honey-ginger syrup – these are traditional home remedies for common ailments like colds and sore throats. The cocktail subtly evokes this comforting, healing association.

Furthermore, the ingredient profile of The Penicillin cocktail bears a striking resemblance to that of a Hot Toddy. A Hot Toddy is a warm beverage, typically made with whiskey, honey, lemon, and spices, which has been historically believed to relieve the symptoms of cold and flu. This connection further reinforces the “medicinal” theme, making the name both witty and entirely appropriate for a drink designed to make you feel good.

Honey and ginger, two of the central ingredients in the Penicillin cocktail // FoodNouveau.com

What Does The Penicillin Cocktail Taste Like?

If you, like me, often find yourself asking the bartender, “What do you have that’s not too sweet?” then The Penicillin cocktail is likely to become your new favorite. This sophisticated drink offers a complex and captivating taste experience that stands out from overly sugary concoctions. It’s a dynamic blend of bright, sour notes from fresh lemon juice, a smoky depth from the Scotch, a subtle spicy warmth from the fresh ginger, and just enough honey to beautifully round out and soften any sharp edges.

Each sip is an exploration of contrasts: the initial tartness gives way to the intriguing peat and malt characteristics of the Scotch, followed by a gentle, lingering heat from the ginger and a comforting sweetness from the honey syrup. It’s remarkably refreshing, yet rich and full-bodied, making it the perfect cocktail to sip slowly and savor, allowing its intricate layers of flavor to unfold on your palate. The experience is truly immersive, engaging multiple senses from the first aromatic whiff to the last lingering taste.

Crafting The Perfect Penicillin: Ingredients and Techniques

Can I Substitute Any Variety of Scotch Whiskey for the Smoky Islay Variety?

The original Penicillin cocktail, as served by Sam Ross at Milk & Honey, featured a distinctive element: a float of smoky Islay Scotch whiskey, which was gently layered over the finished cocktail in a rocks glass, often presented with a straw. This smoky Scotch was not merely an ingredient but a crucial aromatic component. As you took your first sips, the potent, peaty aroma would rise, playing with your senses and creating an incredibly intriguing and delicious sensory experience. It’s this aromatic complexity that truly elevates the drink and makes it so memorable.

Smoky Scotch whiskeys are, as their name suggests, produced in Scotland, with the most famously peated varieties hailing from a small, rugged island known as Islay. Renowned distilleries such as Lagavulin, Laphroaig, and Ardbeg produce some of the most iconic and readily available Islay single malts. These bottles, however, often come with a premium price tag, which can make it a significant investment if you’re only looking to acquire it for a single cocktail recipe.

The Lagavulin Distillery in Islay, Scotland // FoodNouveau.com
The Lagavulin distillery in Islay, Scotland, famed for its peated single malts.

If you’re hesitant to purchase an entire bottle of expensive Islay Scotch, a clever workaround is to reach out to friends who might be Scotch enthusiasts. Many avid drinkers will have a bottle or two of Islay Scotch in their collection and might be willing to share the half-ounce you need to experience the Penicillin cocktail in its authentic, complex form. The aromatic float truly adds an unparalleled layer of depth and interest to the drink.

However, if acquiring a smoky Islay Scotch is not feasible, do not despair! You can absolutely still make a delicious Penicillin cocktail by simply skipping the Islay float and using any good quality blended Scotch whiskey for the main body of the drink. When choosing a blended Scotch, I personally recommend opting for one that is well-balanced, perhaps with a slight sweetness, and a hint of smokiness, if possible. A great example of such a Scotch is Johnnie Walker Red Label. Its inherent, subtle smokiness contributes a wonderful flavor and aroma, ensuring your Penicillin cocktail remains complex and satisfying even without the distinct Islay float.

Scotch Whiskey Cocktail: The Penicillin // FoodNouveau.com

Tips for Making a Stellar Penicillin Cocktail

  • Fresh Ingredients are Key: Always use freshly squeezed lemon juice. Bottled juice simply won’t yield the same vibrant, zesty flavor that is essential for this cocktail’s balance.
  • Honey Syrup for Smoothness: Plain honey can be too thick and difficult to dissolve in cold liquids. Honey syrup, which is a simple mixture of equal parts honey and hot water, ensures seamless integration and a perfectly smooth texture. Make a batch and keep it refrigerated for up to two weeks.
  • Gentle Muddling of Ginger: When muddling the fresh ginger slices, apply gentle pressure. The goal is to release its aromatic oils and spicy juices, not to pulverize it into a pulp. Over-muddling can make the drink too fibrous or overly spicy.
  • Proper Shaking Technique: Fill your shaker generously with ice cubes. Shake vigorously for about 15-20 seconds, until the shaker is frosty on the outside. This achieves optimal chilling and dilution, which is crucial for a well-balanced cocktail.
  • Large Ice Cubes: Serve your Penicillin in a rocks glass with a large ice cube or sphere. Larger ice melts slower, preventing your drink from becoming watered down too quickly, preserving its intense flavors.
  • Garnish Matters: A thin slice of fresh ginger for garnish isn’t just for looks. It adds an extra aromatic element that enhances the overall drinking experience.
Scotch Whiskey Cocktail: The Penicillin // FoodNouveau.com
Print Recipe
Pin Recipe

Scotch Whiskey Cocktail: The Penicillin

The Penicillin is a Scotch Whiskey cocktail made with lemon, honey, and ginger. Find out how to make it and what earned the drink its intriguing name!
Prep Time:5 minutes
Cook Time:2 minutes
Cooling Time (for the Honey Syrup):1 hour
Servings 1 cocktail
Author Marie Asselin

Ingredients

US Customary / Metric
  • oz blended Scotch one that’s more sweet than smoky, and not too expensive, such as Johnny Walker Red Label
  • ½ oz Islay single malt Scotch such as Lagavulin, Caol Ila, Laphroaig, or Ardbeg (optional)
  • 1 oz freshly squeezed lemon juice
  • 1 oz honey syrup (see note)
  • 3 thin slices fresh ginger

Instructions

  • Place the slices fresh ginger in a shaker and use a wooden muddler or wooden spoon to muddle it until it is bruised and broken up. Add the blended Scotch, Islay single malt Scotch, lemon juice, and honey syrup, and add lots of ice cubes. Shake until the cocktail is icy cold, about 20 seconds.
  • Strain in a glass filled with ice cubes. Garnish with an additional slice of ginger, and enjoy right away.
  • NOTE: How to make honey syrup: Mix equal parts honey and water, and heat until the two are fully combined. Store in an airtight glass jar and refrigerate for up to two weeks.

Did you make this?

Tell me how you liked it! Leave a comment or take a picture and tag it with @foodnouveau on Instagram.

Disclosure Notice: This site is a participant in the Amazon Associates Program, an affiliate advertising program designed to provide a means for the site to earn fees by linking to Amazon and affiliated sites.

If you click on an affiliate link, I may earn advertising or referral fees if you make a purchase through such links, at no extra cost to you. This helps me create new content for the blog–so thank you! Learn more about advertising on this site by reading my Disclosure Policy.